Every game on the Opening Day board with the pitching matchups, betting lines, and key trends. No fluff, just the data you need.
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Pirates at Mets (1:15 PM ET)
Paul Skenes (1.97 ERA, 2.36 FIP, NL Cy Young 2025) vs Freddy Peralta (2.70 ERA). Mets ML -118, Total 7.0. Skenes went 10-10 despite a sub-2.00 ERA with 216 K in 187.2 IP. Mets finished 2025 with the highest team payroll in baseball.
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White Sox at Brewers (2:10 PM ET)
Shane Smith (3.81 ERA) vs Jacob Misiorowski (4.36 ERA). Brewers ML -186, Total 8.0. White Sox lost 100+ games in 2025 for the second straight season. Brewers won the NL Central in 2025.
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Nationals at Cubs (2:20 PM ET)
Cade Cavalli (4.25 ERA) vs Matthew Boyd (3.21 ERA). Cubs ML -232, Total 7.5. Cubs added Alex Bregman (5yr/$175M) to a lineup with strong depth. Nationals finished last in the NL East in 2025.
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Twins at Orioles (3:05 PM ET)
Joe Ryan (3.42 ERA) vs Trevor Rogers (1.81 ERA in 109.2 IP after trade to BAL). Orioles ML -143, Total 8.0. Rogers had a breakout second half with Baltimore in 2025. Orioles added Pete Alonso (5yr/$155M).
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Red Sox at Reds (4:10 PM ET)
Garrett Crochet (2.59 ERA, 255 K in 205.1 IP, led MLB in K) vs Andrew Abbott (2.87 ERA, All-Star). Red Sox ML -158, Total 8.0. Crochet was 18-5 with a 2.89 FIP in his first full season with Boston.
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Angels at Astros (4:10 PM ET)
Jose Soriano (4.26 ERA) vs Hunter Brown (2.43 ERA). Astros ML -186, Total 8.0. Astros are heavy home favorites behind Brown's breakout 2025 season. Angels finished under .500 in 2025.
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Tigers at Padres (4:10 PM ET)
Tarik Skubal (2.21 ERA, 2.45 FIP, 241 K, back-to-back AL Cy Young) vs Nick Pivetta (2.87 ERA, 3.49 FIP). Tigers ML -136, Total 7.0. Petco Park runs factor sits at 94 (below league average). Skubal's 0.89 WHIP was best among AL starters.
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Rangers at Phillies (4:15 PM ET)
Nathan Eovaldi (1.73 ERA) vs Cristopher Sanchez (2.50 ERA). Phillies ML -156, Total 8.0. Eovaldi posted a career-best 1.73 ERA in 2025. Sanchez emerged as a legit frontline starter for Philadelphia.
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Rays at Cardinals (4:15 PM ET)
Drew Rasmussen (2.76 ERA) vs Matthew Liberatore (4.21 ERA). Rays ML -122, Total 7.5. Rasmussen returned healthy and strong in 2025 after missing time. Cardinals were sellers at the 2025 deadline.
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Dodgers at Diamondbacks (8:30 PM ET, NBC/Peacock)
Yoshinobu Yamamoto (2.49 ERA, 2025 World Series MVP) vs Zac Gallen (4.83 ERA). Dodgers ML -259, Total 9.0. Dodgers won back-to-back World Series in 2024-25 and added Kyle Tucker (4yr/$240M). Heaviest favorite on the board.
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Guardians at Mariners (10:10 PM ET)
Tanner Bibee (4.24 ERA) vs Logan Gilbert (3.44 ERA). Mariners ML -193, Total 6.5. Lowest total on the board at T-Mobile Park where runs factor was bottom-3 in MLB. Gilbert had a 2.89 ERA at home in 2025.